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Dysport 500iu Ipsen UK

Dysport 500iu Ipsen UK

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Technical characteristics
  • Type toolsGel
Description

Dysport 500IU

Dysport contains the substance called botulinum toxin type A as its active ingredient. Inactive ingredients of Dysport

include human albumin, lactose and protein from cow’s milk.

Dysport was originally developed for the treatment of neurological and ophthalmic conditions in the early 1990s in the

United Kingdom and has established clinical success. Patients with excessive sweating under the armpits (axillary

hyperhidrosis) are also treated with this product.

Dysport is manufactured by Ipsen Biopharm Ltd., a British company with headquarters in Wrexham, UK. Dysport is

exclusively distributed by Tercica, Inc., a subsidiary company of Ipsen Group with headquarters at Brisbane, CA and

Medicis Aesthetics Inc., a wholly owned subsidiary of Medicis Pharmaceutical Corporation with headquarters at Scottsdale,

AZ.

Pharmacological Action

Dysport contains substance called botulinum toxin type A that relaxes the muscle. Botulinum toxin is derived from

Clostridium botulinum bacteria that intercept the discharge of acetylcholine from the nerve endings that causes the

contraction of muscles.

For the improvement of the appearance of glabellar lines, Dysport temporarily impede the tightening of muscles found

between the eyebrows for about 4 months.

For the treatment of abnormal head position and neck pain caused by cervical dystonia (CD), Dysport lessens the muscle

spasm that causes the CD by softening the muscle for about 12 to 16 weeks. Neck pain and abnormal head position as

symptoms to CD is thereby reduced.

Dysport works in two functions, which is by inhibiting the release of acetylcholine and at the same time blocks the

neuromuscular activity.

Dysport Indication

Dysport is indicated for the treatment of the following conditions specifically indicated in the medication guide:

    Abnormal head position (spasmodic torticolitis) and neck pain brought about by the condition called cervical dystonia

(CD) in adults,
    Temporary improve the appearance of moderate to severe frown lines found between the eyebrows (glabellar lines) in

patients younger than 65 years old.

Dysport 500IU? is also prescribed for the medication of the following condition:

    Arm spasticity (stiffness in the arm muscles) that occurs following a stroke.
    Equinus foot deformity (abnormal ankle position and walking gait) caused by cerebral palsy spasticity in children 2

years old or older.
    Blepharospasm (a condition affecting the eyelid). This condition losses the persons’ control on the blinking and

closure of his eyelids.
    Hemifacial spasm (a condition affecting the face muscle). Persons’ affected with this condition losses control on his

face muscle, enabling it to contract without control.

Mode of Administration

Dysport is administered through intramuscular injection on the affected muscles. It should be performed by a health care

provider who is trained and has the skill of identifying the essential attributes of muscles.

For the treatment of cervical Dystonia: Dysport is administered with the initial divided dose of Dysport 500IU? given

through intramuscular injection in affected muscles. Depending upon the result of treatment and patient’s response to

medication, Dysport may be administered every 12-16 weeks or as prescribed by Doctor with a dosage between 250 to 1000

units.

For the improvement of Glabellar lines: Dysport is administered intramuscularly in the affected muscles not exceeding the

total dose of 50 Units, divided in 10 aliquot units or for 5 equal dosages.

Intervals or frequency for re-treatment must not transpire less than 3 months (12 weeks) following the previous injection

or administration.

Contraindications and Cautions

Dysport is contraindicated to persons who have an allergic reaction to any Dysport ingredients. It is important to inform

your Doctor if you have either an infection on the possible site for injection or are allergic to the following

substance:

    Protein from cow’s milk
    Botulinum toxin such as Botox or Myobloc

Persons who have the following symptoms or conditions are advised to tell your Doctor of your concern and the possible

effect of Dysport on your current condition:

    Asthma or Emphysema
    Abnormal sugar level or Diabetes
    Bleeding problems
    Irregular heartbeat

Dysport and Breastfeeding. It is not known whether Dysport passes in to breast milk. It is however important to inform

your Doctor if you are breast feeding a baby to avoid harm to the nursing infant.

Dysport and Pregnancy. FDA classified Dysport under the C category for pregnancy. Dysport should be used with caution on

pregnant women, as such; benefits should exceed the risk that is involved in the use of this medication.

Dysport may cause muscle weakness and must not be taken by persons who are operating machinery or driving a vehicle.

Dysport is generally not recommended to patients under 18 years old.

Dysport Side Effects

Like any medication, side effects may occur on the use of this medication. The side effect that is associated on the use

of Dysport varies from moderate to serious classification.

Moderate or less serious side effects: The following side effects will diminish after couple of hours:

    Discomfort and pain at the injection site
    Headache
    Tired feeling
    Muscle pain
    Neck pain
    Mild allergic reaction such as itching, rash, dizziness and faint
    Dropping eyelids
    Blurred vision

Serious side effects: Immediately seek medical intervention if any of the following side effects occurs. Spread of toxin

may cause serious side effects in the area outside the injection site and is usually accompanied by the following

symptoms:

    Dysphonia (change or loss of voice or the occurrence of hoarse voice )
    Dysarthria ( trouble speaking a word clearly)
    Breathing trouble
    Swallowing problem
    Severe wheezing and asthma symptoms
    Loss of bladder control

It is important to inform your doctor right away if you have any discomfort or unnatural occurrence in your present

condition.

Drug Interactions

Drug interactions will normally affect the efficacy of the treatment. There is no solid study that is conducted on the

possible interaction of Dysport to certain medication.

The following treatment that interferes with neuromuscular transmission may affect the efficacy of Dysport:

    Aminoglycosides (curare-like agents)
    Anticholinergic drugs
    Other Botulinum Neurotoxins

It is however important to inform your medical practitioner of any medication you are currently taking for him to have a

complete assessment of its possible interaction with Dysport.

Interesting facts

Dysport is already existing for more than 2 decades and was first to have gained the approval for treatment of

neuromuscular conditions in New Zealand.

Currently, it has received the approval for the treatment of frown lines and excessive sweating under the armpits. Such

fact is registered under the New Zealand Medicines Act.

Dysport Review:

“I tried Dysport after my friend recommends the product to me. I basically use Botox previously and was able to compare

the effects between the two products.

Botox is good, I felt it effects 3 days after the injection. After using Dysport, I am amazed of the result; I already

felt it one day after. It definitely works better than Botox and its effect last longer.Dysport is simply amazing.”

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