Dysport contains the substance called botulinum toxin type A as its active ingredient. Inactive ingredients of Dysport
include human albumin, lactose and protein from cow’s milk.
Dysport was originally developed for the treatment of neurological and ophthalmic conditions in the early 1990s in the
United Kingdom and has established clinical success. Patients with excessive sweating under the armpits (axillary
hyperhidrosis) are also treated with this product.
Dysport is manufactured by Ipsen Biopharm Ltd., a British company with headquarters in Wrexham, UK. Dysport is
exclusively distributed by Tercica, Inc., a subsidiary company of Ipsen Group with headquarters at Brisbane, CA and
Medicis Aesthetics Inc., a wholly owned subsidiary of Medicis Pharmaceutical Corporation with headquarters at Scottsdale,
Dysport contains substance called botulinum toxin type A that relaxes the muscle. Botulinum toxin is derived from
Clostridium botulinum bacteria that intercept the discharge of acetylcholine from the nerve endings that causes the
contraction of muscles.
For the improvement of the appearance of glabellar lines, Dysport temporarily impede the tightening of muscles found
between the eyebrows for about 4 months.
For the treatment of abnormal head position and neck pain caused by cervical dystonia (CD), Dysport lessens the muscle
spasm that causes the CD by softening the muscle for about 12 to 16 weeks. Neck pain and abnormal head position as
symptoms to CD is thereby reduced.
Dysport works in two functions, which is by inhibiting the release of acetylcholine and at the same time blocks the
Dysport is indicated for the treatment of the following conditions specifically indicated in the medication guide:
Abnormal head position (spasmodic torticolitis) and neck pain brought about by the condition called cervical dystonia
(CD) in adults,
Temporary improve the appearance of moderate to severe frown lines found between the eyebrows (glabellar lines) in
patients younger than 65 years old.
Dysport 500IU? is also prescribed for the medication of the following condition:
Arm spasticity (stiffness in the arm muscles) that occurs following a stroke.
Equinus foot deformity (abnormal ankle position and walking gait) caused by cerebral palsy spasticity in children 2
years old or older.
Blepharospasm (a condition affecting the eyelid). This condition losses the persons’ control on the blinking and
closure of his eyelids.
Hemifacial spasm (a condition affecting the face muscle). Persons’ affected with this condition losses control on his
face muscle, enabling it to contract without control.
Mode of Administration
Dysport is administered through intramuscular injection on the affected muscles. It should be performed by a health care
provider who is trained and has the skill of identifying the essential attributes of muscles.
For the treatment of cervical Dystonia: Dysport is administered with the initial divided dose of Dysport 500IU? given
through intramuscular injection in affected muscles. Depending upon the result of treatment and patient’s response to
medication, Dysport may be administered every 12-16 weeks or as prescribed by Doctor with a dosage between 250 to 1000
For the improvement of Glabellar lines: Dysport is administered intramuscularly in the affected muscles not exceeding the
total dose of 50 Units, divided in 10 aliquot units or for 5 equal dosages.
Intervals or frequency for re-treatment must not transpire less than 3 months (12 weeks) following the previous injection
Contraindications and Cautions
Dysport is contraindicated to persons who have an allergic reaction to any Dysport ingredients. It is important to inform
your Doctor if you have either an infection on the possible site for injection or are allergic to the following
Protein from cow’s milk
Botulinum toxin such as Botox or Myobloc
Persons who have the following symptoms or conditions are advised to tell your Doctor of your concern and the possible
effect of Dysport on your current condition:
Asthma or Emphysema
Abnormal sugar level or Diabetes
Dysport and Breastfeeding. It is not known whether Dysport passes in to breast milk. It is however important to inform
your Doctor if you are breast feeding a baby to avoid harm to the nursing infant.
Dysport and Pregnancy. FDA classified Dysport under the C category for pregnancy. Dysport should be used with caution on
pregnant women, as such; benefits should exceed the risk that is involved in the use of this medication.
Dysport may cause muscle weakness and must not be taken by persons who are operating machinery or driving a vehicle.
Dysport is generally not recommended to patients under 18 years old.
Dysport Side Effects
Like any medication, side effects may occur on the use of this medication. The side effect that is associated on the use
of Dysport varies from moderate to serious classification.
Moderate or less serious side effects: The following side effects will diminish after couple of hours:
Discomfort and pain at the injection site
Mild allergic reaction such as itching, rash, dizziness and faint
Serious side effects: Immediately seek medical intervention if any of the following side effects occurs. Spread of toxin
may cause serious side effects in the area outside the injection site and is usually accompanied by the following
Dysphonia (change or loss of voice or the occurrence of hoarse voice )
Dysarthria ( trouble speaking a word clearly)
Severe wheezing and asthma symptoms
Loss of bladder control
It is important to inform your doctor right away if you have any discomfort or unnatural occurrence in your present
Drug interactions will normally affect the efficacy of the treatment. There is no solid study that is conducted on the
possible interaction of Dysport to certain medication.
The following treatment that interferes with neuromuscular transmission may affect the efficacy of Dysport:
Aminoglycosides (curare-like agents)
Other Botulinum Neurotoxins
It is however important to inform your medical practitioner of any medication you are currently taking for him to have a
complete assessment of its possible interaction with Dysport.
Dysport is already existing for more than 2 decades and was first to have gained the approval for treatment of
neuromuscular conditions in New Zealand.
Currently, it has received the approval for the treatment of frown lines and excessive sweating under the armpits. Such
fact is registered under the New Zealand Medicines Act.
“I tried Dysport after my friend recommends the product to me. I basically use Botox previously and was able to compare
the effects between the two products.
Botox is good, I felt it effects 3 days after the injection. After using Dysport, I am amazed of the result; I already
felt it one day after. It definitely works better than Botox and its effect last longer.Dysport is simply amazing.”