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R-ALA increases your muscles uptake of glycogen. This increases muscle cell volume and contributes to that full pumped feeling when you workout. This is a very desirable effect as the increase in muscle glycogen also increases other important nutrient transport that contributes to cell volume and muscle growth. R-ALA is not a thermogenic but it does appear to contribute to favorable body composition changes. This is believed to be due to a nutrient partitioning effect where nutrients are channeled more to lean tissue and away from fat tissue. R-ALA will help enhance the efficiency of many different supplements. One in particular is Creatine HSC. R-ALA will help enhance the absorption of creatine into the muscle cell by providing a transport vehicle by it's unique ability to mimic insulin. As we said in an earlier answer, you must use R-ALA in a capsule form and not in a pre-mixed powder.
R-ALA is also one of the most potent antioxidants available. And, when taken with other antioxidants it actually enhances their antioxidant abilities.
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AST R-ALA Nitric Oxide/Vasodilator Sports Nutrition